Elliott , ribonuclease To with Kenji Takahashi , 2',3'-cyclic nucleotide 3'-phos- phohyctrolase from brain with Arabinda Guha, David C. So- gin, and Robert I. Drummond , and carboxypepticiase Y with Rikimaru Hayashi.
Stein took a particular interest in the application of the chromatographic methods to the analysis of physiological. STEIN fluids for amino acids. One of his earliest uses of the proce dure was in a quantitative study of the major ninhy lrin-pos- itive constituents of human urine.
Biographical Memoirs: V.80 (Biographical Memoirs: A Series)
He extendecT his studies to cystinuria, and the laboratory, in collaboration with Alexan- der Bearn of The Rockefeller Hospital, investigates! Part of that stucly required adaptation of the method to the measurement of blood plasma amino acids as well. In cooperation with Harris Tal- lan, the free amino acids of mammalian tissues were also surveyed in cletail.
In a study with Alejan lro C. One of the first applications of the amino acid analysis procedure was to human hemoglobin A prepares! That stucly led to a reex- amination with R. David Cole of the cysteine content of human hemoglobin. He was a visiting professor at the University of Chicago in , ant! His lectures there, throughout his travels, and to graduate stu- clents at Rockefeller conveyed an exciting picture of the ho- rizons that new methods were opening in the stucly of the chemical structure of proteins.
He was a member of the Med- ical Advisory Boarc! He was vice-chairman of the U.
Neurobiology of Sensation and Reward.
His major pastimes were directly related to the life of a scientist with international interests. The American Society of Biological Chemists drew upon his editorial skill, beginning in , when he was elected to the Eclitorial Committee. He was chairman of the Committee from to He was an active participant in the search that lect to the appointment of John Eclsall to the editorship of The journal of Biological Chemistry in S, upon the retire- ment of Rudolph I. Stein joined the Editorial Board of the journal in In his drafts of editorial letters he was quick to praise a fine manuscript, to decline an inacl- equate one, and careful to explain in gracious cletai!
Two years later he was asked by Ecisall to assume one of the three associate editorships. As Edsall's ten-year term as editor drew toward a close, Stein was asked by the Council of the Society to consider the position. He accepted and took a leading part in setting up the administrative procedures that wouIcl facilitate the han- dling of the increasing numbers of manuscripts that were being received as the journal grew in size.
The changes in- cludect the organization of a permanent central office at the Society's headquarters in Bethesda to which all manuscripts wouIcT go initially.
Stein hacI earlier hac! Harte as full-time executive secre- tary of the Society; Harte was macle business manager of the Journal and Edith Wolff was the first executive assistant. A staff was thus establishecI to hancIle the innumerable business details associated with receiving more than 3, manu- scripts annually and managing the publication of editorially acceptable texts. Stein's foresight in centralizing the first step in the edito- rial process, with the view of facilitating the transfer of the editorship to the next recipient, was tested-tragically- much too soon.
He was stricken by major illness in , after a year and a half in the position. In , while in attendance at an international sympo- sium on proteolytic enzymes being held in Copenhagen, Stein clevelopec! A few clays later, en route home by air, paralysis began. He barely survived the acute phase of the disease, which was cliagnosect as a severe case of GuilIain-Barre syndrome. After a year of hospitali- zation, he remained a quadriplegic. He met this tragedy with great courage and with preservation of his sense of humor. His wife anc!
The Rockefeller Univer- sity, uncler the administrations of Frederick Seitz and Joshua Lederberg, was host to Stein's determinecT endeavors during eleven years of this difficult existence. He, of course, hac! Stein hac! When the laboratory's work. Work from several laboratories on the presence of RNases of the pancreatic type in most mammalian cells ant!
Stein followed with enthusiasm the researches of the young associates in the laboratory on the isolation of the inhibitor in pure form from human placenta anc! He made the uncomfortable jour- ney by wheelchair to his office at Rockefeller whenever he felt able, ant! On occasion, they wouic! He took an active interest in reacting manuscripts and his editorial skill was always helpful.
With the stimulating cooperation of Phoebe Stein, their home continued to be the scene of vis its by scientists from arounc! A life of sixty-eight years filled with unusual measures of accomplishment, acclaim, anti suffering came to a close on February 2, , when William Stein diecI suddenly from heart failure at his home in New York.
Among the many honors that Stein received were election to the National Academy of Sciences in and to the American Academy of Arts and Sciences in the same year. Academic honors included D. The composition of elastin. With Carl Niemann and Max Bergmann.
#14-175 Best Memoire & Biography Books of 2016
The quantitative deter- mination of amino acids. A new principle for the determination of amino acids, and its application to collagen and gelatin. With Max Bergmann. Naphthalenesulfonic acid as a reagent for amino acids. Determination of proline in mixtures con- taining 1- and dl-proline. The praline content of gelatin. With David G.
Doherty and Max Bergmann. Aromatic sulfonic acids as reagents for amino acids. The isolation of l-serine from silk fibroin. The preparation of l-serine, I-phenylalanine, and l-leucine from protein hydrolysates. With Stanford Moore and Max Bergmann. The specific rotation of l-tyrosine. Some current problems and recent advances in the chemistry of the proteins.
Fifth Annul Meet.
Dorothy Hill | Australian Academy of Science
Protein constituent analysis by the solubility method. Determination of amino acids by the solu- bility product method. Aromatic sulfonic acids as reagents for peptides. Partial hydrolysis of silk fibroid. With Stanford Moore. The use of specific precipitants in the amino acid analysis of proteins.
With Joseph S. Fruton and Max Bergmann. Chemical reactions of the nitrogen mustard gases. The reactions of the nitro- gen mustard gases with protein constituents. Fruton, Mark A. Stahmann, and Calvin Golumbic. The re- actions of the nitrogen mustard gases with chemical compounds of biological interest. Chemical reactions of mustard gas and related compounds. The transformations of mustard gas in water. Formation and properties of sulfonium salts derived from mustard gas.
- Dorothy Hill 1907-1997!
- Catalog Record: Biographical memoirs | HathiTrust Digital Library.
- I Am a Man!: Race, Manhood, and the Civil Rights Movement.
- The Bro Code.
- About this memoir?
- Orion Authority - The Team.
With Stanford Moore and Joseph S. The reaction of mus- tard gas with carboxyl groups and with the amino groups of amino acids and peptides.